69
/ 100
Mostly True
Astaxanthin is a unique xanthophyll with benefits like reducing lipid peroxidation, improving dyslipidemia, and preserving skin moisture. It may have side effects like blunting Nrf2 adaptations and increasing serum ALT.
Infact verdict: Mostly True (69/100).
The claims about astaxanthin's health benefits and side effects are supported by varying degrees of evidence. For lipid peroxidation, evidence supports a reduction in MDA but lacks specificity for isoprostane F2α. Dyslipidemia improvements are supported by studies showing HDL-C elevation and triglyceride reduction, though results vary. Muscle damage attenuation is supported by evidence showing reduced CK and LDH levels. Skin benefits are corroborated by studies showing improved elasticity and moisture. The claim about blunting Nrf2 adaptations is supported by animal studies, but human evidence is lacking. The increase in serum ALT is supported by meta-analysis data. The claim about 5α-reductase inhibition lacks direct evidence of neurosteroid depletion, though inhibition is documented. Overall, the claims are mostly supported by scientific studies, but some lack comprehensive human data.
How is this score determined? →Individual claims
58
Mixed
Health
Astaxanthin reduces 15-isoprostane F2α by 59% and MDA by 31–33%.
Evidence supports the reduction of MDA by 31-33%, but the reduction percentage for 15-isoprostane F2α is not specified. This results in a mixed score due to partial evidence.
Fact Check Score
None
Fact Check Weight
0
Web Consensus Score
60
Web Consensus Weight
40
Source Quality Score
50
Source Quality Weight
20
Llm Reasoning Score
60
Llm Reasoning Weight
40
Llm Reasoning Score Raw
60
Weighted Total
58
Evidence Summary
Web evidence supports MDA reduction, lacks specific data for isoprostane F2α.
72
Mostly True
Health
Astaxanthin elevates HDL-C and lowers triglycerides by 17–26% in hyperlipidemics.
Multiple studies support the claim that astaxanthin elevates HDL-C and lowers triglycerides, though results vary by dosage and population.
Fact Check Score
None
Fact Check Weight
0
Web Consensus Score
75
Web Consensus Weight
40
Source Quality Score
70
Source Quality Weight
20
Llm Reasoning Score
70
Llm Reasoning Weight
40
Llm Reasoning Score Raw
70
Weighted Total
72
Evidence Summary
Multiple studies support HDL-C elevation and triglyceride reduction.
86
True
Health
Astaxanthin attenuates exercise-induced muscle damage with CK SMD = -0.45 and LDH SMD = -0.93.
Evidence supports the claim with studies showing significant reductions in CK and LDH levels, indicating reduced muscle damage.
Fact Check Score
None
Fact Check Weight
0
Web Consensus Score
80
Web Consensus Weight
40
Source Quality Score
75
Source Quality Weight
20
Llm Reasoning Score
70
Llm Reasoning Weight
40
Llm Reasoning Score Raw
70
Weighted Total
86
Evidence Summary
Studies show significant reductions in CK and LDH levels.
88
True
Health
Astaxanthin preserves dermal elasticity and moisture even at 4 mg every other day.
Multiple studies confirm that astaxanthin improves skin elasticity and moisture, supporting the claim.
Fact Check Score
None
Fact Check Weight
0
Web Consensus Score
85
Web Consensus Weight
40
Source Quality Score
80
Source Quality Weight
20
Llm Reasoning Score
75
Llm Reasoning Weight
40
Llm Reasoning Score Raw
75
Weighted Total
88
Evidence Summary
Studies confirm improvements in skin elasticity and moisture.
60
Mostly True
Health
Supraphysiological dosing of astaxanthin during endurance training can blunt endogenous Nrf2, GPx, and CAT adaptations.
Animal studies support the claim that high doses of astaxanthin can blunt antioxidant enzyme activity, but human evidence is lacking.
Fact Check Score
None
Fact Check Weight
0
Web Consensus Score
65
Web Consensus Weight
40
Source Quality Score
60
Source Quality Weight
20
Llm Reasoning Score
55
Llm Reasoning Weight
40
Llm Reasoning Score Raw
55
Weighted Total
60
Evidence Summary
Animal studies support enzyme activity blunting; human data lacking.
70
Mostly True
Health
Prolonged supplementation of astaxanthin produces a small but statistically significant increase in serum ALT.
Meta-analysis data supports the claim of a small increase in serum ALT with astaxanthin supplementation.
Fact Check Score
None
Fact Check Weight
0
Web Consensus Score
75
Web Consensus Weight
40
Source Quality Score
70
Source Quality Weight
20
Llm Reasoning Score
65
Llm Reasoning Weight
40
Llm Reasoning Score Raw
65
Weighted Total
70
Evidence Summary
Meta-analysis supports small increase in serum ALT.
50
Mixed
Health
Astaxanthin's inhibition of 5α-reductase can precipitate neurosteroid and DHT depletion.
While astaxanthin inhibits 5α-reductase, direct evidence of neurosteroid depletion is lacking. The claim remains speculative without human data.
Fact Check Score
None
Fact Check Weight
0
Web Consensus Score
55
Web Consensus Weight
40
Source Quality Score
50
Source Quality Weight
20
Llm Reasoning Score
45
Llm Reasoning Weight
40
Llm Reasoning Score Raw
45
Weighted Total
50
Evidence Summary
Inhibition of 5α-reductase documented; neurosteroid depletion speculative.
