58
/ 100
Mixed
The text discusses toxicity levels, drug interactions, and contraindications of a substance, including its effects on enzymes, potential risks during pregnancy, and overdose symptoms.
Infact verdict: Mixed (58/100).
The claims regarding toxicity levels, drug interactions, and contraindications were evaluated based on available evidence. The claim about oral LD50 being greater than 5,000 mg/kg in mice and rats is partially supported by evidence for methanol extract of A. Squamosa leaves but lacks specific data for other substances. The claim about intraperitoneal administration being toxic with an LD50 of 2,000 mg/kg is not supported by the evidence, which shows different LD50 values. The non-toxicity of hydroethanolic extract to rat astrocytes at 10–100 μg/mL is supported by one source. The claim about tetraphyllin B content lacks specific quantification. The arbutin content claim is not directly supported by evidence. The claim about strong inhibition of CYP3A4 with IC50 approximately 6 μg/mL is not directly supported. The additive risk of hypoglycemia with insulin and sulfonylureas is supported by evidence. The reduction of non-heme iron absorption by 59%–67% with meals is supported. The contraindication during pregnancy, lactation, and childhood is generally supported for certain substances. The claim about extreme acute overdose causing severe symptoms is supported by general evidence on herbal overdoses.
How is this score determined? →Individual claims
58
Mixed
Health
Oral LD50 is greater than 5,000 mg/kg in mice and rats.
The evidence supports that the oral LD50 for the methanol extract of A. Squamosa leaves is more than 5,000 mg/kg, but specific data for mice and rats for other substances is not provided.
Fact Check Score
None
Fact Check Weight
0
Web Consensus Score
60
Web Consensus Weight
40
Source Quality Score
60
Source Quality Weight
20
Llm Reasoning Score
60
Llm Reasoning Weight
40
Llm Reasoning Score Raw
60
Weighted Total
58
Evidence Summary
Web evidence supports LD50 > 5,000 mg/kg for methanol extract of A. Squamosa leaves.
27
Mostly False
Health
Intraperitoneal administration is toxic with an LD50 of 2,000 mg/kg.
The evidence does not support an LD50 of 2,000 mg/kg for intraperitoneal administration. Different studies report varying LD50 values.
Fact Check Score
None
Fact Check Weight
0
Web Consensus Score
20
Web Consensus Weight
40
Source Quality Score
20
Source Quality Weight
20
Llm Reasoning Score
20
Llm Reasoning Weight
40
Llm Reasoning Score Raw
20
Weighted Total
27
Evidence Summary
No evidence supports an LD50 of 2,000 mg/kg for intraperitoneal administration.
65
Mostly True
Health
Hydroethanolic extract is non-toxic to rat astrocytes at 10–100 μg/mL.
One source supports the non-toxicity of hydroethanolic extract to rat astrocytes at 10–100 μg/mL, while another source does not provide relevant information.
Fact Check Score
None
Fact Check Weight
0
Web Consensus Score
70
Web Consensus Weight
40
Source Quality Score
70
Source Quality Weight
20
Llm Reasoning Score
70
Llm Reasoning Weight
40
Llm Reasoning Score Raw
70
Weighted Total
65
Evidence Summary
One source supports non-toxicity of hydroethanolic extract to rat astrocytes.
42
Mixed
Health
Contains approximately 0.26% tetraphyllin B.
The evidence mentions the presence of tetraphyllin B but does not provide specific quantification of 0.26%.
Fact Check Score
None
Fact Check Weight
0
Web Consensus Score
40
Web Consensus Weight
40
Source Quality Score
40
Source Quality Weight
20
Llm Reasoning Score
40
Llm Reasoning Weight
40
Llm Reasoning Score Raw
40
Weighted Total
42
Evidence Summary
Presence of tetraphyllin B mentioned, but no specific quantification.
42
Mixed
Health
Arbutin content is approximately 0.7%.
The evidence does not provide a definitive answer for the exact arbutin content of 0.7%.
Fact Check Score
None
Fact Check Weight
0
Web Consensus Score
40
Web Consensus Weight
40
Source Quality Score
40
Source Quality Weight
20
Llm Reasoning Score
40
Llm Reasoning Weight
40
Llm Reasoning Score Raw
40
Weighted Total
42
Evidence Summary
No definitive evidence for arbutin content of 0.7%.
42
Mixed
Health
Strong inhibition of CYP3A4 with IC50 approximately 6 μg/mL.
The specific IC50 value of 6 μg/mL is not directly supported by the evidence provided.
Fact Check Score
None
Fact Check Weight
0
Web Consensus Score
40
Web Consensus Weight
40
Source Quality Score
40
Source Quality Weight
20
Llm Reasoning Score
40
Llm Reasoning Weight
40
Llm Reasoning Score Raw
40
Weighted Total
42
Evidence Summary
No direct support for IC50 value of 6 μg/mL.
88
True
Health
Additive risk of hypoglycemia with insulin, sulfonylureas, and glitazones.
The evidence supports an increased risk of hypoglycemia when insulin and sulfonylureas are combined, though the clinical significance is noted as small.
Fact Check Score
None
Fact Check Weight
0
Web Consensus Score
80
Web Consensus Weight
40
Source Quality Score
80
Source Quality Weight
20
Llm Reasoning Score
80
Llm Reasoning Weight
40
Llm Reasoning Score Raw
80
Weighted Total
88
Evidence Summary
Evidence supports increased hypoglycemia risk with insulin and sulfonylureas.
91
True
Health
Non-heme iron absorption is reduced by 59%–67% if taken with meals.
The evidence supports that non-heme iron absorption is significantly reduced when taken with meals, particularly with tea or coffee.
Fact Check Score
None
Fact Check Weight
0
Web Consensus Score
85
Web Consensus Weight
40
Source Quality Score
85
Source Quality Weight
20
Llm Reasoning Score
85
Llm Reasoning Weight
40
Llm Reasoning Score Raw
85
Weighted Total
91
Evidence Summary
Evidence supports significant reduction in non-heme iron absorption with meals.
65
Mostly True
Health
Contraindicated during pregnancy, lactation, and childhood.
The evidence supports contraindications for certain substances during pregnancy, lactation, and childhood, though not universally for all substances.
Fact Check Score
None
Fact Check Weight
0
Web Consensus Score
70
Web Consensus Weight
40
Source Quality Score
70
Source Quality Weight
20
Llm Reasoning Score
70
Llm Reasoning Weight
40
Llm Reasoning Score Raw
70
Weighted Total
65
Evidence Summary
Evidence supports contraindications for certain substances during pregnancy and lactation.
58
Mixed
Health
Extreme acute overdose of 200 g extract causes severe symptoms.
The evidence supports that extreme overdoses of certain herbal extracts can cause severe symptoms, though specific data for a 200 g extract is not provided.
Fact Check Score
None
Fact Check Weight
0
Web Consensus Score
60
Web Consensus Weight
40
Source Quality Score
60
Source Quality Weight
20
Llm Reasoning Score
60
Llm Reasoning Weight
40
Llm Reasoning Score Raw
60
Weighted Total
58
Evidence Summary
General evidence supports severe symptoms from extreme herbal overdoses.
